For most, it's a good idea for one person to tackle the inside and one person to tackle the outside. Then, check the other's work by running through the list. Two sets of eyes are better than one.
Make sure all the switches and systems in your RV are turned off. You don't want to drain the auxiliary battery. This includes:
Lower the TV antenna & satellite dish
Retract cell phone booster
Stow outside items
Retract leveling system or jacks
Grab and store chocks & levelers
Close and lock outside storage compartments
Secure bike rack
Retract and secure awning(s)
Disconnect and store: -water hose -septic hose -cable TV wire -electric cords
Check the cap on your sewer connection
Turn gas supply off at the source
Before you pull out, make sure you check your campsite for anything you might have missed. Remember to properly dispose of all your garbage and bottles.
Before you take off, make sure you run through this checklist to check your RV and towing vehicle. Safety first.
Make the trip a little easier for your towing rig. Dump your gray and black tanks. For boondockers, you may opt to leave your freshwater tank full (or partially full) if freshwater isn't on your route.